This fourth post, long-awaited by two people, concludes a two-part post based on my having to watch Disney’s Cinderella roughly 17837 times. After a while, you start noticing the little things, or go mad, or both.
Like a Freudian psycho-analyst asking about mom, screens bring up issues for classical geneticists. Screens are what we do. Conceptually, screens are simple. In fact, they are like your screen door. The goal is start with everything and separate it into two groups – one that passes the screen and one excluded by the screen – based on a particular characteristic. Your screen door tries to do this based on size, letting in the breeze, but keeping out the flies, if everything is working well.
With screens, be they in the genetics laboratory or your back door, the devil is in the details. We need to worry about how well the screen works. If our screen door has holes in it or we are opening the door a lot, bugs are going to get in. If the screen is dirty, it might not let as much of the breeze through as we would like. We need to worry about whether we are actually screening for the characteristic we care about. Screen doors separate bugs from breeze based on size. They do not detect “bug” and zap it with a laser, because one house could not contain that much awesome.
I’m concerned that the King, Grand Duke, and Prince did not think through the details of their attempt to screen their female subjects for Cinderella – i.e., The Great Slipper Screen. Continue reading “Cinde-really 4: The Great Slipper Screen”