It is almost impossible to study basic cellular mechanisms in humans. This is why scientists spend so much time trying to find animal models for human diseases. Sometimes, there is a naturally occurring disease in animals that is analogous to a human condition. Other times, the animal’s genome can be modified to replicate mutations that are found in human diseases. However, despite the best efforts of many scientists, models often fail to faithfully replicate all aspects of human disease.
This led to the creation of a new mouse model of spontaneously developing Creutzfeldt-Jakob disease (CJD) by the Lindquist lab at MIT. Continue reading “Making mouse diseases more like human diseases”