During my postdoc in Jernej Ule’s lab at the Laboratory of Molecular Biology in Cambridge (UK), we studied the genome-wide regulation of splicing (aka, alternative splicing, but these days all splicing is “alternative”). This involved integrating information on protein-RNA interactions with information on splicing isoforms (mRNA transcript variants from the same gene) from next generation sequencing. I could spend hours talking to you about how complicated this type of thing can get. Or, I can show you this figure from Eduardo Eyras.
Needless to say (but I’m going to anyway), I am pleased as punch that my lab’s most recent offering unto the body of scientific literature (“Analysis of alternative splicing associated with aging and neurodegeneration in the human brain”) was put on the cover of the current issue of Genome Research. In this paper, we investigated the connections between alternative splicing profiles in the aging brain and in brains suffering from neurodegenerative disorders, like Alzheimer’s disease. It is important to note that we were characterizing the alternative splicing differences associated with aging and disease, not identifying splicing changes that cause the diseases or the symptoms. Such questions will require ongoing work, which this study will, hopefully, help guide. Continue reading “Coming to news stands. . .”