The 6 Million Dollar Man would have been made with optogenetics

I was reading this 2010 review of optogenetics (PDF) by Karl Deisseroth, a pioneer in the field, and was struck by this sentence:

Optogenetics is a technology that allows targeted, fast control of precisely defined events in biological systems as complex as freely moving mammals.

Then I read this in a recent paper in Science:

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities.

My immediate thought was: cyborgs.

Over at Pacific Standard, you can read the results: Our Cyborg Overlords May Arrive Sooner Than Expected.

It’s shocking how fast biotech is growing. For a long time we had restriction enzymes, ligases, PCR. Now we have GFP, RNAi, ZFNs and TALENs, optogenetics, CRISPRs…

Meet the Backwards Butterfly

A few days ago, a colleague of mine was visiting. When I say colleague, I clearly mean friend that is also a biologist, but I like to pretend that we’re not just up all night drinking and talking about polyandry in frogs. Amidst the usual back and forth game of “no way…did you see that new species they found in wherever”, he mentioned a backwards butterfly. “Did you know about the butterfly that has coloration on its wings to make it look like it’s backwards?” …”uh…no…is that really a thing?”

Photo Credit:Rick Cech Tambopata Research Center, Peru
Photo Credit:Rick Cech
Tambopata Research Center, Peru

When my friend shared the picture I had no reply (which almost never happens). Damn. Evolution you are amazing. High five natural selection…high fives all around.

Behold the Zebra Hairstreak (Panthiades bathildis)… Not only are the stripes on the wings going the wrong way, but the ends of the wings look like antennae. Continue reading “Meet the Backwards Butterfly”

The paradox of more science funding, less research… we’ve seen this before

Does this sound familiar?

Since 19XX, overall federal research funding in all fields has shown a steady increase, resulting in greater than 40 percent growth (adjusted for inflation) from 19XX to 19XX. University-based researchers have been the primary beneficiaries of this growth. Although the data are harder to come by, relevant Figures from [Agency X] and several universities indicate that the growth in funding for XXX research has been comparable to these overall trends.

However, these figures lump together many different kinds of projects and funders. For example, one element of xxx funding is the base-funded (or core) program, which is the primary source of support for small science endeavors. This report looks at base-funded programs at both NSF and [Agency X] and finds, contrary to the trends described above, that they have not even kept up with inflation and have certainly not been able to keep pace with the explosion in grant requests. As a result, grant sizes have decreased, and the percentage of proposals accepted has dropped. A rough calculation shows that researchers must now write two to four proposals per year to remain funded, up from one or two in 19XX. Of course, increasing the time spent searching for support means that less time is spent on productive research. Rising university overhead and fringe benefit costs, that consume more and more of each grant dollar exacerbate this problem. Clearly, the base-funded program has not participated proportionately in the overall XXX research funding increase. Although we do not attempt to quantify the effect this has had on the quality of science produced, we do find that the core program has become much less efficient during the past decade. We also infer that the lion’s share of new funding has gone into project-specific funding, most of which involves big science efforts.

I’ve blanked out a few things… can you guess what area of research and what time period this refers to? The answer is below the fold. Continue reading “The paradox of more science funding, less research… we’ve seen this before”

Inception for Mice

fear1Inception is real. At least that’s what the interwebs have been saying this week. A lab at MIT headed by Nobel prize winner, Susumu Tonegawa, has implanted a memory in mouse’s brain. What they did was really cool but it’s definitely nothing like Inception. Continue reading “Inception for Mice”

Meet the Tuatara

“Tuatara, Nga Manu, Waikanae, New Zealand, 15 April 2006” – Photo: PhilipC, Contrast Enhanced: Samsara (Creative Commons Attribution 2.0 Generic)

The tuatara is often referred to as a living fossil because his buddies went extinct around 100 million years. They live in New Zealand and there are two species.

There have been reports of tuataras living up to 200 years. Henry the proud new father in the video below is 111!

“Meet the…” is a collaboration between The Finch & Pea and Nature Afield to bring Nature’s amazing creatures into your home.